Dr. Lukas A. Basedow


Postdoctoral Researcher



Dept. of Psychology - Clinical Psychology and Psychotherapy I


Phillips Universität Marburg



DNA methylation changes associated with cannabis use and verbal learning performance in adolescents: an exploratory whole genome methylation study.


Journal article


Melina Wiedmann, Sören Kuitunen-Paul, Lukas A. Basedow, Max Wolff, Nataliya DiDonato, Julia Franzen, Wolfgang Wagner, Veit Roessner, Yulia Golub
Translational Psychiatry, vol. 12(317), 2022


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APA
Wiedmann, M., Kuitunen-Paul, S., Basedow, L. A., Wolff, M., DiDonato, N., Franzen, J., … Golub, Y. (2022). DNA methylation changes associated with cannabis use and verbal learning performance in adolescents: an exploratory whole genome methylation study. . Translational Psychiatry, 12(317).

Chicago/Turabian
Wiedmann, Melina, Sören Kuitunen-Paul, Lukas A. Basedow, Max Wolff, Nataliya DiDonato, Julia Franzen, Wolfgang Wagner, Veit Roessner, and Yulia Golub. “DNA Methylation Changes Associated with Cannabis Use and Verbal Learning Performance in Adolescents: an Exploratory Whole Genome Methylation Study. .” Translational Psychiatry 12, no. 317 (2022).

MLA
Wiedmann, Melina, et al. “DNA Methylation Changes Associated with Cannabis Use and Verbal Learning Performance in Adolescents: an Exploratory Whole Genome Methylation Study. .” Translational Psychiatry, vol. 12, no. 317, 2022.


ABSTRACT
 The association between extent of chronic cannabis use (CCU-extent) and cognitive impairment among adolescents has been the subject of controversial debate. Linking DNA methylation to CCU-extent could help to understand cannabis associated changes in cognitive performance. We analyzed cognitive task performances, CpG methylation in peripheral whole-blood samples and selfreported past-year CCU-extent of n = 18 adolescents (n = 9 psychiatric outpatients with chronic cannabis use (CCU), n = 9 without) who were matched for age, gender and psychiatric disorders. Patients with CCU were at least 24 h abstinent when cognitive tasks were performed. A Principal Component Analysis (PCA) was carried out to identify group differences in whole genome DNA methylation. Mediation analyses were performed between CCU-extent associated CpG sites and CCU-extent associated variables of cognitive tasks. PCA results indicated large differences in whole genome DNA methylation levels between the groups that did not reach statistical significance. Six CpG sites revealed reduced methylation associated with CCU-extent. Furthermore, CCU-extent was associated with lower scores in verbal learning. All six CpG sites mediated the effects between CCU-extent and verbal learning free recall. Our results indicate that CCU is associated with certain patterns in the methylome. Furthermore, CCU-extent associated impairments in memory function are mediated via differential methylation of the six CCU-associated CpG sits. Six identified CpG are located in genes previously described in the context of neurodegeneration, hippocampus-dependent learning and neurogenesis. However, these results have to be carefully interpreted due to a small sample size. Replication studies are warranted. 


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